Prostaglandin E2-Induced Inhibition of the In Vitro Immune Response by SRBC-Stimulated Human Lymphocytes

Abstract Exogenous PGE2 strongly inhibits the response of human lymphocyte cultures to SRBC. This effect is mediated through a T cell inhibition since non-T cells are not significantly affected. Indomethacin, which inhibits in this system lymphocyte endogenous PGE2 synthesis increases the in vitro i...

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Veröffentlicht in:Immunopharmacology and immunotoxicology 1991, Vol.13 (1-2), p.169-181
Hauptverfasser: Misefari, A., Valenti, A., Cavallaro, A., Sofo, V., Santarpia, G., Salmeri, F. M., Teti, D. Venza
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Sprache:eng
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Zusammenfassung:Abstract Exogenous PGE2 strongly inhibits the response of human lymphocyte cultures to SRBC. This effect is mediated through a T cell inhibition since non-T cells are not significantly affected. Indomethacin, which inhibits in this system lymphocyte endogenous PGE2 synthesis increases the in vitro immune response. the effect of indomethacin is overcame by exogenous PGE2. These data may be relevant for explaining the immunomodulatory role of PGE2 following antigen challenge.
ISSN:0892-3973
1532-2513
DOI:10.3109/08923979109019698