L-Asparaginase (Leunase) Induced Pancreatitis in Childhood Acute Lymphoblastic Leukemia

A major complication of L-asparaginase therapy in acute lymphoblastic leukemia (ALL) is pancreatitis. Among the 915 cases of ALL seen over last 10 years, 19 (2%) developed pancreatitis. Median age was 5.5 years with a median duration of symptoms of 4 weeks. All cases had raised serum amylase and lip...

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Veröffentlicht in:	Pediatric hematology and oncology 1998, Vol.15 (6), p.533-538
Hauptverfasser:	Sahu, S., Saika, S., Pai, S. K., Advani, S. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukemia Adolescent Amylases - blood Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Asparaginase - adverse effects Asparaginase - therapeutic use Biological and medical sciences Child Child, Preschool childhood Drug toxicity and drugs side effects treatment Humans L-asparaginase Lipase - blood Medical sciences pancreatitis Pancreatitis - blood Pancreatitis - chemically induced Pancreatitis - physiopathology Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Toxicity: digestive system
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Zusammenfassung:	A major complication of L-asparaginase therapy in acute lymphoblastic leukemia (ALL) is pancreatitis. Among the 915 cases of ALL seen over last 10 years, 19 (2%) developed pancreatitis. Median age was 5.5 years with a median duration of symptoms of 4 weeks. All cases had raised serum amylase and lipase. Pancreatitis was not related to the dose/duration of L-asparaginase therapy. Ultrasonography can be used as a corroborative investigation for diagnosis along with serum chemistries. Close clinical monitoring of children for early diagnosis of this complication is recommended.
ISSN:	0888-0018 1521-0669
DOI:	10.3109/08880019809018315