Oral Ondansetron: An Effective Ambulatory Complement to Intravenous Ondansetron in the Control of Chemotherapy-Induced Nausea and Vomiting in Children

One hundred children with non-central nervous system malignancies received ondansetron at initiation of chemotherapy and every 8 hours for 5 days after cisplatin-containing therapy and for 3 days after other chemotherapy. Ondansetron was administered orally except with the intravenous chemotherapy....

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Veröffentlicht in:Pediatric hematology and oncology 1995, Vol.12 (1), p.67-72
Hauptverfasser: Cohen, Ian J., Zehavi, Nurit, Buchwald, Ilana, Yaniv, Yitzchak, Goshen, Yakov, Kaplinsky, Chaim, Zaizov, Rina
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Sprache:eng
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Zusammenfassung:One hundred children with non-central nervous system malignancies received ondansetron at initiation of chemotherapy and every 8 hours for 5 days after cisplatin-containing therapy and for 3 days after other chemotherapy. Ondansetron was administered orally except with the intravenous chemotherapy. For the chemotherapy days, 72 of 93 children (76%) had complete or major control of vomiting on their worst day, 25% with cisplatin-containing protocols, 60% with ifosfamide-containing protocols, and 82% with other protocols. For the overall period, 71 of 93 children (76%) reported complete or major control of vomiting on the worst day, 14% with cisplatin, 60% with ifosfamide, and 83% with other chemotherapy. All had mild or no nausea. Of the 355 chemotherapy days, 228 children (64%) were emesisfree, 40% with cisplatin, 60% with ifosfamide, and 68% with other regimens. Of the overall period (541 days), 393 days were emesisfree, 45% with cisplatin, 71% with ifosfamide, and 86% with other regimes. Sixty-nine patients were not hospitalized, and oral ondansetron was given when chemotherapy was completed. Of the 241 ambulatory chemotherapy days, 178 (74%) were emesisfree. No significant toxicity was encountered. Oral ondansetron reduced hospitalization without reducing antiemetic efficiency in children.
ISSN:0888-0018
1521-0669
DOI:10.3109/08880019509029530