Significance of mast cell renal infiltration in patients with anti-GBM nephritis
To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into gro...
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| Veröffentlicht in: | Renal failure 2016-07, Vol.38 (6), p.906-913 |
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| creator | Wu, Xiao-Mei Zhang, Yi-Yan Zhang, Ming-Chao Zhang, Li-Hua Zeng, Cai-Hong Liu, Zhi-Hong Tang, Zheng |
| description | To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs |
| doi_str_mv | 10.3109/0886022X.2016.1164184 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3109_0886022X_2016_1164184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1799556025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-46390b8eb52b702b128e2a6efd63ac391203d2c46875209a5f799288e14c0e0d3</originalsourceid><addsrcrecordid>eNp9kMFKAzEQhoMotlYfQcnRy9Yku8lmb2rRKigKKngL2d3ERnaTmqSUvr1Z2nr0NDPw_TPDB8A5RtMco-oKcc4QIZ9TgjCbYswKzIsDMMaU0IyhojoE44HJBmgETkL4RghTXpJjMCIlqmhO2Bi8vpkva7RppG0UdBr2MkTYqK6DXlnZQWO16aKX0TibBrhMnbIxwLWJCyhtNNn89hlatVx4E004BUdadkGd7eoEfNzfvc8esqeX-ePs5ilrCpzHrGB5hWquakrqEpEaE66IZEq3LJdNXmGC8pY0BeMlJaiSVJdVRThXuGiQQm0-AZfbvUvvflYqRNGbMPwtrXKrIHDiKU2KaELpFm28C8ErLZbe9NJvBEZikCn2MsUgU-xkptzF7sSq7lX7l9rbS8D1FkiSnO_l2vmuFVFuOue1T0ZNGPb_d-MXcGSC-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1799556025</pqid></control><display><type>article</type><title>Significance of mast cell renal infiltration in patients with anti-GBM nephritis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><creator>Wu, Xiao-Mei ; Zhang, Yi-Yan ; Zhang, Ming-Chao ; Zhang, Li-Hua ; Zeng, Cai-Hong ; Liu, Zhi-Hong ; Tang, Zheng</creator><creatorcontrib>Wu, Xiao-Mei ; Zhang, Yi-Yan ; Zhang, Ming-Chao ; Zhang, Li-Hua ; Zeng, Cai-Hong ; Liu, Zhi-Hong ; Tang, Zheng</creatorcontrib><description>To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs <50 mm
−2
, n = 18) and group 2 (MCs ≥50 mm
−2
, n = 20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95 ± 3.66 vs. 4.75 ± 2.73 mg/dL, p < 0.001), urine retinol-binding protein (RBP 29.8 ± 13.9 vs. 15.7 ± 11.5 mg/dL, p = 0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7 ± 21.9 vs. 47.0 ± 33.6%, p = 0.037) but a lower percentage of cellular crescents. More CD8 (268 mm
−2
vs. 180 mm
−2
, p = 0.045) and CD68 (268 mm
−2
vs. 180 mm
−2
, p = 0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.3109/0886022X.2016.1164184</identifier><identifier>PMID: 27095326</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Anti-GBM nephritis ; Anti-Glomerular Basement Membrane Disease - pathology ; Chronic Disease ; chronic inflammation ; chronic lesions ; Creatinine - blood ; Female ; Fibrosis ; Humans ; Immunohistochemistry ; Kidney - pathology ; Male ; mast cells ; Mast Cells - cytology ; Middle Aged ; Osmotic Pressure ; renal function ; Retinol-Binding Proteins - urine ; Young Adult</subject><ispartof>Renal failure, 2016-07, Vol.38 (6), p.906-913</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-46390b8eb52b702b128e2a6efd63ac391203d2c46875209a5f799288e14c0e0d3</citedby><cites>FETCH-LOGICAL-c413t-46390b8eb52b702b128e2a6efd63ac391203d2c46875209a5f799288e14c0e0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27095326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Xiao-Mei</creatorcontrib><creatorcontrib>Zhang, Yi-Yan</creatorcontrib><creatorcontrib>Zhang, Ming-Chao</creatorcontrib><creatorcontrib>Zhang, Li-Hua</creatorcontrib><creatorcontrib>Zeng, Cai-Hong</creatorcontrib><creatorcontrib>Liu, Zhi-Hong</creatorcontrib><creatorcontrib>Tang, Zheng</creatorcontrib><title>Significance of mast cell renal infiltration in patients with anti-GBM nephritis</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs <50 mm
−2
, n = 18) and group 2 (MCs ≥50 mm
−2
, n = 20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95 ± 3.66 vs. 4.75 ± 2.73 mg/dL, p < 0.001), urine retinol-binding protein (RBP 29.8 ± 13.9 vs. 15.7 ± 11.5 mg/dL, p = 0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7 ± 21.9 vs. 47.0 ± 33.6%, p = 0.037) but a lower percentage of cellular crescents. More CD8 (268 mm
−2
vs. 180 mm
−2
, p = 0.045) and CD68 (268 mm
−2
vs. 180 mm
−2
, p = 0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.</description><subject>Adult</subject><subject>Anti-GBM nephritis</subject><subject>Anti-Glomerular Basement Membrane Disease - pathology</subject><subject>Chronic Disease</subject><subject>chronic inflammation</subject><subject>chronic lesions</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>mast cells</subject><subject>Mast Cells - cytology</subject><subject>Middle Aged</subject><subject>Osmotic Pressure</subject><subject>renal function</subject><subject>Retinol-Binding Proteins - urine</subject><subject>Young Adult</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKAzEQhoMotlYfQcnRy9Yku8lmb2rRKigKKngL2d3ERnaTmqSUvr1Z2nr0NDPw_TPDB8A5RtMco-oKcc4QIZ9TgjCbYswKzIsDMMaU0IyhojoE44HJBmgETkL4RghTXpJjMCIlqmhO2Bi8vpkva7RppG0UdBr2MkTYqK6DXlnZQWO16aKX0TibBrhMnbIxwLWJCyhtNNn89hlatVx4E004BUdadkGd7eoEfNzfvc8esqeX-ePs5ilrCpzHrGB5hWquakrqEpEaE66IZEq3LJdNXmGC8pY0BeMlJaiSVJdVRThXuGiQQm0-AZfbvUvvflYqRNGbMPwtrXKrIHDiKU2KaELpFm28C8ErLZbe9NJvBEZikCn2MsUgU-xkptzF7sSq7lX7l9rbS8D1FkiSnO_l2vmuFVFuOue1T0ZNGPb_d-MXcGSC-w</recordid><startdate>20160702</startdate><enddate>20160702</enddate><creator>Wu, Xiao-Mei</creator><creator>Zhang, Yi-Yan</creator><creator>Zhang, Ming-Chao</creator><creator>Zhang, Li-Hua</creator><creator>Zeng, Cai-Hong</creator><creator>Liu, Zhi-Hong</creator><creator>Tang, Zheng</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160702</creationdate><title>Significance of mast cell renal infiltration in patients with anti-GBM nephritis</title><author>Wu, Xiao-Mei ; Zhang, Yi-Yan ; Zhang, Ming-Chao ; Zhang, Li-Hua ; Zeng, Cai-Hong ; Liu, Zhi-Hong ; Tang, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-46390b8eb52b702b128e2a6efd63ac391203d2c46875209a5f799288e14c0e0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Anti-GBM nephritis</topic><topic>Anti-Glomerular Basement Membrane Disease - pathology</topic><topic>Chronic Disease</topic><topic>chronic inflammation</topic><topic>chronic lesions</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>mast cells</topic><topic>Mast Cells - cytology</topic><topic>Middle Aged</topic><topic>Osmotic Pressure</topic><topic>renal function</topic><topic>Retinol-Binding Proteins - urine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xiao-Mei</creatorcontrib><creatorcontrib>Zhang, Yi-Yan</creatorcontrib><creatorcontrib>Zhang, Ming-Chao</creatorcontrib><creatorcontrib>Zhang, Li-Hua</creatorcontrib><creatorcontrib>Zeng, Cai-Hong</creatorcontrib><creatorcontrib>Liu, Zhi-Hong</creatorcontrib><creatorcontrib>Tang, Zheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Xiao-Mei</au><au>Zhang, Yi-Yan</au><au>Zhang, Ming-Chao</au><au>Zhang, Li-Hua</au><au>Zeng, Cai-Hong</au><au>Liu, Zhi-Hong</au><au>Tang, Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of mast cell renal infiltration in patients with anti-GBM nephritis</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2016-07-02</date><risdate>2016</risdate><volume>38</volume><issue>6</issue><spage>906</spage><epage>913</epage><pages>906-913</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs <50 mm
−2
, n = 18) and group 2 (MCs ≥50 mm
−2
, n = 20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95 ± 3.66 vs. 4.75 ± 2.73 mg/dL, p < 0.001), urine retinol-binding protein (RBP 29.8 ± 13.9 vs. 15.7 ± 11.5 mg/dL, p = 0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7 ± 21.9 vs. 47.0 ± 33.6%, p = 0.037) but a lower percentage of cellular crescents. More CD8 (268 mm
−2
vs. 180 mm
−2
, p = 0.045) and CD68 (268 mm
−2
vs. 180 mm
−2
, p = 0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27095326</pmid><doi>10.3109/0886022X.2016.1164184</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | Adult Anti-GBM nephritis Anti-Glomerular Basement Membrane Disease - pathology Chronic Disease chronic inflammation chronic lesions Creatinine - blood Female Fibrosis Humans Immunohistochemistry Kidney - pathology Male mast cells Mast Cells - cytology Middle Aged Osmotic Pressure renal function Retinol-Binding Proteins - urine Young Adult |
| title | Significance of mast cell renal infiltration in patients with anti-GBM nephritis |
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