Intensification of Peritoneal Dialysis Improves Valacyclovir Neurotoxicity

Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for...

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Veröffentlicht in:	Renal failure 2013-03, Vol.35 (2), p.289-290
Hauptverfasser:	Pipili, Chrysoula, Pantelias, Kostas, Deda, Edmond, Tsiamalos, Pandelis, Kostis, Evaggelos, Grapsa, Eirini
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - therapy Acyclovir - adverse effects Acyclovir - analogs & derivatives Acyclovir - therapeutic use Aged Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Female Follow-Up Studies Herpes Zoster - diagnosis Herpes Zoster - drug therapy Humans intensification Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - therapy Kidney Function Tests life-threatening neurotoxicity peritoneal dialysis Peritoneal Dialysis, Continuous Ambulatory - methods Risk Assessment Treatment Outcome valacyclovir Valine - adverse effects Valine - analogs & derivatives Valine - therapeutic use
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Zusammenfassung:	Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal, our case showed that intensive peritoneal dialysis regimen leads to the recovery of neurotoxicity after 3 days.
ISSN:	0886-022X 1525-6049
DOI:	10.3109/0886022X.2012.743914