Combined Analysis of Smoking, TP53, and FGFR3 Mutations in Tunisian Patients with Invasive and Superficial High-Grade Bladder Tumors

ABSTRACT In our cohort,FGFR3 mutations were detected in 31.1% of bladder tumors and are associated with lower stage and grade. Concerning TP53, 62 mutations were found in tumors from 44 cases (48.88%) and are associated with advanced forms. The combined analysis of FGFR3 and TP53 mutations in our co...

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Veröffentlicht in:	Cancer investigation 2009-11, Vol.27 (10), p.998-1007
Hauptverfasser:	Ouerhani, Slah, Rouissi, Kamel, Kourda, Nadia, Marrakchi, Raja, Bougatef, Karim, Riadh Ben Slama, Mohamed, Sfaxi, Mohamed, Chebil, Mohamed, Ben Jilani, Sarra, Benammar Elgaaied, Amel
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Aged Bladder cancer Carcinoma - ethnology Carcinoma - etiology Carcinoma - genetics Carcinoma - pathology Exons Female FGFR3 mutation Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Male Middle Aged Mutation Neoplasm Invasiveness Neoplasm Staging Odds Ratio Phenotype Population Receptor, Fibroblast Growth Factor, Type 3 - genetics Risk Assessment Risk Factors Smoking Smoking - adverse effects Smoking - ethnology Tp53 mutation Tumor Suppressor Protein p53 - genetics Tunisia Tunisia - epidemiology Urinary Bladder Neoplasms - ethnology Urinary Bladder Neoplasms - etiology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urothelium - pathology
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Zusammenfassung:	ABSTRACT In our cohort,FGFR3 mutations were detected in 31.1% of bladder tumors and are associated with lower stage and grade. Concerning TP53, 62 mutations were found in tumors from 44 cases (48.88%) and are associated with advanced forms. The combined analysis of FGFR3 and TP53 mutations in our cohort showed an independent distribution. In addition, we have reported that FGFR3 mutations spectrum depends on the intensity of tobacco use (pack years: PY). Finally, we have found that the FGFR3wt/TP53mut genotype, which was associated with advanced bladder tumors; was overrepresented in light smokers (PY < 40) compared to nonsmoker patients (p =.01).
ISSN:	0735-7907 1532-4192
DOI:	10.3109/07357900902849707