Release of Urea from Semisolid Formulations Using a Multilayer Membrane System

Release of Urea from Semisolid Formulations Using a Multilayer Membrane System

Abstract A method for the determination of in vitro release of urea from semisolid formulations using a multilayer membrane system (MMS) has been developed. The artificial model membranes consisted of collodion as the matrix and glycerol as the hydrophilic acceptor phase. The method can be employed...

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Veröffentlicht in:Drug development and industrial pharmacy 1997, Vol.23 (3), p.253-257
Hauptverfasser: Knorst, M. T., Neubert, R., Wohlrab, W.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Zusammenfassung:Abstract A method for the determination of in vitro release of urea from semisolid formulations using a multilayer membrane system (MMS) has been developed. The artificial model membranes consisted of collodion as the matrix and glycerol as the hydrophilic acceptor phase. The method can be employed as a tool for comparison of in vitro release profile of semisolid formulations and, thus, can be used as a quality control procedure for assuring lot-to-lot uniformity.
ISSN:0363-9045
1520-5762
DOI:10.3109/03639049709149801