Characterization of Talc Samples from Different Sources

Abstract Nine different kinds of U.S.P. grade talc samples were examined for variations in density, particle size, surface area, tendency of preferred orientation, and maximum ejection force. It was found that U.S.P. grade talcs varied in physical properties. The relationships between various physic...

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Veröffentlicht in:Drug development and industrial pharmacy 1994, Vol.20 (19), p.2993-3003
Hauptverfasser: Lin, Kangwen, Peck, Garnet E.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Nine different kinds of U.S.P. grade talc samples were examined for variations in density, particle size, surface area, tendency of preferred orientation, and maximum ejection force. It was found that U.S.P. grade talcs varied in physical properties. The relationships between various physical properties of talc were analyzed using the Pearson's correlation of coefficient. The results suggested that the talc sample with a higher tendency of preferred orientation has closer bulk packing and talc with lower bulk density and higher surface area requires less peak force to break the tablet/die-wall adhesion.
ISSN:0363-9045
1520-5762
DOI:10.3109/03639049409041963