Sustained Release Tablets of Theophylline
Abstract Sustained release tablets of theophylline (anhydrous) were prepared using hydrophilic polymers (Methyl Cellulose, Methocel K4M and K15M) and hydrophobic polymers (ethyl cellulose, cellulose acetate). In addition water soluble adjuvants were used to modify release rate. With methocel, rapid...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1990, Vol.16 (11), p.1843-1848 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
Sustained release tablets of theophylline (anhydrous) were prepared using hydrophilic polymers (Methyl Cellulose, Methocel K4M and K15M) and hydrophobic polymers (ethyl cellulose, cellulose acetate). In addition water soluble adjuvants were used to modify release rate. With methocel, rapid gelling was observed and release was near zero-order, whereas with hydrophobic polymers release followed Fickian law of diffusion. |
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| ISSN: | 0363-9045 1520-5762 |
| DOI: | 10.3109/03639049009025791 |