The Influence of Granulation Process and Surfactants on the Biopharmaceutical Properties of Phenylbutazone Tablets

Abstract The influence of granulation process on the biopharmaceutical properties of experimental tablets has been studied, using phenyl butazone as a model substance. Four wet granulation procedures were compared. Moreover, in order to assess the influence of some surfactants, four different formul...

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Veröffentlicht in:Drug development and industrial pharmacy 1988, Vol.14 (12), p.1713-1734
Hauptverfasser: Carli, F., Iamartino, P., Signoretti, E. Ciranni
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The influence of granulation process on the biopharmaceutical properties of experimental tablets has been studied, using phenyl butazone as a model substance. Four wet granulation procedures were compared. Moreover, in order to assess the influence of some surfactants, four different formulations were investigated
ISSN:0363-9045
1520-5762
DOI:10.3109/03639048809151983