"In Vitro" - "In Vivo" Correlations of Eight Nitrofurantion Tablet Formulations: Effect of Various Technological Factors
Abstract The bioavailability of eight nitrofurantoin tablet formulations differing in technological respects has been evaluated and correlated with de dissolution curves obtained using USP XXI Ed methods I and II. Method I was found incapable of predicting bioavailability of formulations when Carbop...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1987, Vol.13 (3), p.501-516 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
The bioavailability of eight nitrofurantoin tablet formulations differing in technological respects has been evaluated and correlated with de dissolution curves obtained using USP XXI Ed methods I and II. Method I was found incapable of predicting bioavailability of formulations when Carbopol 934 is used as binder. The influence of the technological factors varied is discussed. |
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| ISSN: | 0363-9045 1520-5762 |
| DOI: | 10.3109/03639048709040187 |