Effect of Flowing Adjuvants on the Homogeneity and the Kinetics of Mixing of Low Dosage Cohesive Powder Mixtures

Abstract One of the major problems encountered in powder mixing, depending on the properties of the constituents of the mix is the inability of low-power mixers to break down powder agglomerates The effects of the addition of two flowing ad juvants (colloidal Aluminium oxide and Aerosil-200R) on the homogeneity of cohesive powder mixtures and on the kinetics of mixing, were investigated It was demonstrated that colloidal Aluminium oxide increases the degree of homogeneity of a 1 % Triamteren-200 mesh lactose mixture blended in a Turbula T2 C mixer, when an appropriate concentration of the adjuvant, corresponding to that which produces the best flowing properties of the excipient was used. Aerosil-200R did not enhance the homogeneity of the mix