Effects of verapamil and diltiazem on hyperthermic cell death in CHO cells

Non-toxic concentrations of verapamil (0.05 and 0.075 mM) and diltiazem (0.10 and 0.25 mM) sensitize CHO cells to heat killing at 44°C. These drugs sensitize by reducing both the shoulder and the slope of the exponential survival curve. Exposure to verapamil or diltiazem in conjunction with the heat...

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Veröffentlicht in:	International journal of hyperthermia 1989, Vol.5 (3), p.383-387
Hauptverfasser:	Coss, Ronald A., Felgar, Raymond E., Stokes, David G., Smith, Nancy N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Survival - drug effects Cricetinae Cricetulus diltiazem Diltiazem - pharmacology Female Hot Temperature hyperthermia Ovary procaine HCl verapamil Verapamil - pharmacology
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