Effects of verapamil and diltiazem on hyperthermic cell death in CHO cells

Effects of verapamil and diltiazem on hyperthermic cell death in CHO cells

Non-toxic concentrations of verapamil (0.05 and 0.075 mM) and diltiazem (0.10 and 0.25 mM) sensitize CHO cells to heat killing at 44°C. These drugs sensitize by reducing both the shoulder and the slope of the exponential survival curve. Exposure to verapamil or diltiazem in conjunction with the heat...

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Veröffentlicht in:International journal of hyperthermia 1989, Vol.5 (3), p.383-387
Hauptverfasser: Coss, Ronald A., Felgar, Raymond E., Stokes, David G., Smith, Nancy N.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Line
Cell Survival - drug effects
Cricetinae
Cricetulus
diltiazem
Diltiazem - pharmacology
Female
Hot Temperature
hyperthermia
Ovary
procaine HCl
verapamil
Verapamil - pharmacology
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Zusammenfassung:Non-toxic concentrations of verapamil (0.05 and 0.075 mM) and diltiazem (0.10 and 0.25 mM) sensitize CHO cells to heat killing at 44°C. These drugs sensitize by reducing both the shoulder and the slope of the exponential survival curve. Exposure to verapamil or diltiazem in conjunction with the heat sensitizer procaine HCl at 44°C reduced cell survival below that observed for procaine plus heat. The mechanism by which verapamil and diltiazem sensitize CHO cells to heat killing is not understood.
ISSN:0265-6736
1464-5157
DOI:10.3109/02656738909140465