Transvascular Escape Rate of Albumin in Liver Cirrhosis, and its Possible Role in Formation of Ascites

Transvascular Escape Rate of Albumin in Liver Cirrhosis, and its Possible Role in Formation of Ascites

Transvascular escape rate of albumin (TERa) was measured with 131I-RISA during hepatic vein catheterization in 10 males (age 46-67) with alcohol abuse and biopsy-verified liver cirrhosis. Portal hypertension (mean wedged hepatic vein pressure 26 ± 6.6 (S.D.) mm Hg), and low serum albumin concentrati...

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Veröffentlicht in:Scandinavian journal of gastroenterology 1977-01, Vol.12 (7), p.877-884
Hauptverfasser: Henriksen, Jens H., Winkler, Kjeld
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Albumin transport kinetics
alcoholic cirrhosis
ascites
hepatic blood flow
Humans
Hypertension, Portal - blood
Liver Circulation
Liver Cirrhosis, Alcoholic - blood
Lymph
lymph flow
Male
Middle Aged
Plasma Volume
portal hypertension
Serum Albumin - metabolism
Serum Albumin, Radio-Iodinated
transvascular escape rate of albumin
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Zusammenfassung:Transvascular escape rate of albumin (TERa) was measured with 131I-RISA during hepatic vein catheterization in 10 males (age 46-67) with alcohol abuse and biopsy-verified liver cirrhosis. Portal hypertension (mean wedged hepatic vein pressure 26 ± 6.6 (S.D.) mm Hg), and low serum albumin concentration (mean 425 ± 90 (S.D.) μmol/l) were present. Diuretic treatment was given to 9 subjects. TERa (mean 11.4 ± 3.1 (S.D.) per cent/hour) was substantially increased (P < 0.001) compared to normals (Parving & Gyntelberg, 1973). A positive correlation between the post-sinusoidal resistance and TERa (r = 0.91, P
ISSN:0036-5521
1502-7708
DOI:10.3109/00365527709181734