A case of childhood hepatitis B virus infection related primary hepatocellular carcinoma with short malignant transformation time

A case of primary hepatocellular carcinoma (PHC) developing in a 10 year old boy who contracted Hepatitis B virus (HBV) infection in the course of maintenance phase chemotherapy for acute lymphoblastic leukemia was seen at University Hospital, Kuala Lumpur. This case is of interest in that it (1) su...

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Veröffentlicht in:	Pathology 1991, Vol.23 (1), p.66-68
Hauptverfasser:	Cheah, P.L., Looi, L.M., Lin, H.P., Yap, S.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use carcinoma Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - pathology Cell Transformation, Neoplastic chemotherapy Child Childhood Hepatitis B - complications Hepatitis B virus Humans leukemia liver Liver Neoplasms - etiology Liver Neoplasms - pathology Male Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Time Factors
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Beschreibung
Zusammenfassung:	A case of primary hepatocellular carcinoma (PHC) developing in a 10 year old boy who contracted Hepatitis B virus (HBV) infection in the course of maintenance phase chemotherapy for acute lymphoblastic leukemia was seen at University Hospital, Kuala Lumpur. This case is of interest in that it (1) supports an etiological relationship between HBV infection and PHC, (2) manifested a distinctly short malignant transformation time, and (3) draws attention to the possible contributory role of chemotherapy in increasing the risk of developing PHC.
ISSN:	0031-3025 1465-3931
DOI:	10.3109/00313029109061443