Molecular mechanisms of transcription through chromatin by RNA polymerase III: Part 2

Nucleosome forms a so-called nucleosome barrier, which is a serious difficulty for a transcriptional apparatus. We considered studies of formation and nucleosome barrier closing by some types of RNA polymerases. We showed that different polymerases use similar mechanisms for chromatin transcription. We present data testifying to the high similarity between transcriptional and ATP-dependent chromatin remodeling. We propose a nucleosome-mediated model of transcription.