computer system for the analysis of molecular evolution modes of protein-encoding genes (SAMEM): The relationship between molecular evolution and phenotypic traits

An online computer system for the analysis of the molecular evolution modes of genes and proteins has been developed (SAMEM: http://pixie.bionet.nsc.ru/samem). SAMEM computations are based on the ratio of radical to conservative amino acid substitutions (K R /K C ), the rate of amino acid substitutions in the course of protein evolution (V P ), and statistical relationships between the evolutionary changes of all known amino acid properties and particular features of an organism. The system facilitates the interpretation of the results of K R /K C and V P analyses.