Nitric oxide plays a role in the protective effects of short-term adaptation to hypoxia on the stress-induced disorders in rats of the Krushinsky-Molodkina strain

The NO-synthase inhibitor L-NNA (2.5 mg/100 g) abolished the protective effects of short-term adaptation to hypoxia (1 h, 5000 m above sea level) on the development of stress-induced disorders on the model of acoustic stress in the Krushinskii-Molodkina rats genetically predisposed to audiogenic seizures. Using the electronic spine resonance method (ESR) we also demonstrated an increase in NO production during short-term hypoxia in the blood and spleen. The results suggest that NO plays a positive role in protective effects of short-term adaptation to hypoxia.