Role of transcription factors in transdifferentiation of the gastric mucosa

Role of transcription factors in transdifferentiation of the gastric mucosa

The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by its own promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The loss of CDX2 expression in the nuclei of metapla...

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Veröffentlicht in:Cytology and genetics 2015-03, Vol.49 (2), p.113-117
Hauptverfasser: Vernygorodskyi, S. V., Degtiariova, L. V., Iatsyna, O. I., Blume, Ya. B., Yemets, A. I.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Human Genetics
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Zusammenfassung:The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by its own promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The loss of CDX2 expression in the nuclei of metaplastic epithelium may serve as a predictor of gastric mucosa malignization.
ISSN:0095-4527
1934-9440
DOI:10.3103/S0095452715020115