A case of Good's syndrome complicated by graft-versus-host disease-like skin lesion

This case involved a 57-year-old female. She visited her family doctor with a complaint of sustained fever persisting for the previous 2 months. Laboratory data revealed hypogammaglobulinemia, and chest CT showed an anterior mediastinal tumor. Since her skin rash was rapidly worsening, skin biopsy was performed, and a graft-versus-host disease (GVHD) -like reaction was noted. Steroid pulse therapy was administered, and the skin lesions gradually reduced. Thoracoscopic thymothymectomy was carried out. The pathological diagnosis was type B1 thymoma, and we made a diagnosis of Good's syndrome complicated with TAMA. This patient recovered without postoperative infection or relapse of skin lesions. A case of Good's syndrome complicated with TAMA is extremely rare.