A case of anaphylactic shock induced by TachoSil® during surgery

A male in his 70's presented with a right lung tumor after undergoing resection of rectal carcinoma and a metastatic lung tumor. Partial resection of the right lower lobe was performed for the lung tumor. Air leakage developed after the procedure, and the leak was covered with a TachoSil® tissue-sealing sheet. The patient exhibited a sudden reduction in blood pressure after 20 minutes, which we considered to be due to anaphylactic shock caused by TachoSil®, as he also exhibited flushing of the facial surface and all four limbs, with little or no effect of treatment with ephedrine and phenylephrine. Notably, his blood pressure recovered five minutes after removing TachoSil® and providing saline lavage. Physicians should consider the possibility of anaphylactic shock induced by the use of TachoSil® during surgery if a patient shows a significant reduction in blood pressure.