Antibiotic prophylaxis for pulmonary resection of lung cancer

To evaluate the safety of one-day antibiotic prophylaxis, we retrospectively analyzed 153 consecutive cases of major pulmonary resection for lung cancer. The A group (n=66) received 2 g of cefazolin for four days. The B group (n=87) received 2 g of cefazolin only on the operative day. There was no significant difference concerning the patient characteristics, operation procedures, and postoperative events. No surgical site infection occurred in either group. One-day antibiotic prophylaxis is safe and effective for the pulmonary resection of lung cancer.