Production and use of first row transition metal PET radionuclides, 43,44 Sc, 52 Mn, and 45 Ti

With the increasing focus on a more personalized approach to medicine using imaging techniques for patient selection for targeted treatment or "theranostic" strategies, interest in the development of new radionuclides is expanding. Through the development of production and radiochemistry techniques, several new radiometals are being added to the toolbox of the nuclear imaging community. Sc, Mn, and Ti are all emerging transition metal radionuclides and will be discussed in this short review. Each of these nuclides has unique imaging characteristics and shows promise for the development of new molecular imaging agents.