Chronological analysis for the hepatocellular carcinoma development

We chronologically analyzed the hepatocellular carcinoma cases during 1885 to 2005 every five years, i.e. 1st. term (1986∼90), 2nd. term (1991∼95), 3rd. term (1996∼2000), 4th. Term (2001∼05), respectively. HBV group has slightly decreased, HCV group has slightly increased and alcoholic group whose ethanol consumption is over 80g per day for more than 10 years and UN group in which HBV, HCV and AL group were excluded has remained unchanged in frequency, respectively. Female's percentage of HCC development has increased. The age of HCC development has been getting older year by year, except for HBV group which has remained unchanged. The percentage of chronic hepatitis in noncarcinomatous part of the liver has increased. The age of HCC development is significantly lower in patients with DM, on the other hand significantly higher in patients with hypertension. The above results suggest that we must pay attention to HCC development even in case of histologically or clinically chronic hepatitis in the elderly patients.