Clinical evaluation of percutaneous ethanol injection therapy (PEIT) to large hepatocellular carcinomas: The experimental and clinical studies of contrast medium-PEIT (CM-PEIT)
To evaluate the therapeutic effect of percutaneous ethanol inlection therapy (PEIT) to large hepatocellular carcinomas (HCC) (over 30mm in diameter), we have demonstrated contrast-medium PEIT (CM-PEIT). CM-PEIT is a newly developed methods that HCC nodules are punctured by a needle under ultrasound...
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Veröffentlicht in: | Kanzo 1998/06/25, Vol.39(6), pp.379-389 |
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Format: | Artikel |
Sprache: | jpn |
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Zusammenfassung: | To evaluate the therapeutic effect of percutaneous ethanol inlection therapy (PEIT) to large hepatocellular carcinomas (HCC) (over 30mm in diameter), we have demonstrated contrast-medium PEIT (CM-PEIT). CM-PEIT is a newly developed methods that HCC nodules are punctured by a needle under ultrasound imaging and inlected with ethanol mixed with water-soluble contrast medium (Iopamidol containing 370mg/ml iodine) (vol/vol: 7/3) (CME). In this study, CM-PEIT was evaluated on experimental and clinical studies. In elemental study, ethanol at various concentrations (30%, 50%, 70% and 100%) was injected to DAB-induced rat hepatomas. Histological findings of rat hepatomas following the injection of 70% ethanol were similar to those of rat hepatomas injected 100% ethanol. Completely enhanced rat hepatoma nodules on soft X-p tumorgraphy after 70% CME injection was revealed histologically complete necrosis. In clinical study, CM-PEIT was performed to large HCCs and the therapeutic effect was evaluated by CT tumorgraphy and X-p tumorgraphy. The area spreaded into HCC nodules by 70% CME on CT tumorgraphy was the same as that of histologically complete necrosis on surgical resection or autopsy. Completely enhanced large HCC nodules on X-p tumorgraphy after 70% CME injection showed almost histologically complete necrosis. These results suggest that CM-PEIT is a new useful method to evaluate the therapeutic effect of PEIT on large HCCs. |
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ISSN: | 0451-4203 1881-3593 |
DOI: | 10.2957/kanzo.39.379 |