A case of lupoid hepatitis associated with idiopathic thrombocytopenic purpura

A lupoid hepatitis associated with idiopathic thrombocytopenic purpura (ITP) was reported. In this report we focused mainly on the changes in anti-sulfatide autoantibody. A 42-year-old female who complained of knee-joint pain and severe general fatigue at the onset. While transaminase levels improved as a result of SNMC administration which had been started before diagnosis, the levels of γ-gl remained high. Prednisolone was administered to counter advancement of thrombocytopenia. Subsequently, the levels of transaminase, γ-gl and platelet count returned to normal levels. Upon the marked decreas in the platelet count, anti-thrombocyte and anti-sulfatide IgM antibody became positive. It has been reported that anti-sulfatide is a target antigen in autoimmune hepatitis and ITP. Therefore, it was considered interesting that changes of these autoantibodies could be followed up in a case of autoimmune hepatitis associated with ITP.