Expression of proto-oncogenes during liver regeneration

Expression of proto-oncogenes during liver regeneration

We investigated the expression of proto-oncogenes during liver regeneration. The expression of c-myc increased 8 fold between 3-6 hrs following the increase of c-fos m-RNA 30min after partial hepatectomy. Also, the expression of c-fos was induced in primary culture of hepatocytes by the addition of...

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Veröffentlicht in:Kanzo 1988/03/25, Vol.29(3), pp.377-381
Hauptverfasser: FURUSAWA, Shunichi, HAYASHI, Norio, YASHIMA, Takashi, KASAHARA, Akinori, SASAKI, Yutaka, KOUNO, Michikazu, KATAYAMA, Kazuhiro, YAMAZOE, Mituyoshi, FUSAMOTO, Hideyuki, SATO, Nobuhiro, KAMADA, Takenobu
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container_end_page 381
container_issue 3
container_start_page 377
container_title Kanzo
container_volume 29
creator FURUSAWA, Shunichi
HAYASHI, Norio
YASHIMA, Takashi
KASAHARA, Akinori
SASAKI, Yutaka
KOUNO, Michikazu
KATAYAMA, Kazuhiro
YAMAZOE, Mituyoshi
FUSAMOTO, Hideyuki
SATO, Nobuhiro
KAMADA, Takenobu
description We investigated the expression of proto-oncogenes during liver regeneration. The expression of c-myc increased 8 fold between 3-6 hrs following the increase of c-fos m-RNA 30min after partial hepatectomy. Also, the expression of c-fos was induced in primary culture of hepatocytes by the addition of EGF or the serum obtained fron hepatectomized rats, but c-myc m-RNA increased only by the serum after partial hepatectomy. These results suggest that the proto-oncogenes have an important role in the process of liver regeneration.
doi_str_mv 10.2957/kanzo.29.377
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title Expression of proto-oncogenes during liver regeneration
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