Expression of proto-oncogenes during liver regeneration

Expression of proto-oncogenes during liver regeneration

We investigated the expression of proto-oncogenes during liver regeneration. The expression of c-myc increased 8 fold between 3-6 hrs following the increase of c-fos m-RNA 30min after partial hepatectomy. Also, the expression of c-fos was induced in primary culture of hepatocytes by the addition of...

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Veröffentlicht in:Kanzo 1988/03/25, Vol.29(3), pp.377-381
Hauptverfasser: FURUSAWA, Shunichi, HAYASHI, Norio, YASHIMA, Takashi, KASAHARA, Akinori, SASAKI, Yutaka, KOUNO, Michikazu, KATAYAMA, Kazuhiro, YAMAZOE, Mituyoshi, FUSAMOTO, Hideyuki, SATO, Nobuhiro, KAMADA, Takenobu
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Sprache:eng ; jpn
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Zusammenfassung:We investigated the expression of proto-oncogenes during liver regeneration. The expression of c-myc increased 8 fold between 3-6 hrs following the increase of c-fos m-RNA 30min after partial hepatectomy. Also, the expression of c-fos was induced in primary culture of hepatocytes by the addition of EGF or the serum obtained fron hepatectomized rats, but c-myc m-RNA increased only by the serum after partial hepatectomy. These results suggest that the proto-oncogenes have an important role in the process of liver regeneration.
ISSN:0451-4203
1881-3593
DOI:10.2957/kanzo.29.377