Experimental studies on extension of resectability of the liver in dogs: with special reference to changes of lipid peroxide and effect of Coenzyme Q10

The purpose of this investigation was to elucidate pathophisiology and to obtain the survival of dogs after 84% hepatectomy, generally resulting poor prognosis. The study showed that the amount of lipid peroxide in the plasma and remnant liver increased much more after 84% hepatectomy than after 70% hepatectomy, causing significant impairment of the remnant liver function. To prevent hepatic dysfunction after hepatectomy, Coenzyme Q10, an antioxidant and membrane stabilizer, was administered, reducing the increase of lipid peroxide in the plasma and remnant liver, and restoring the liver function with subsequent good regeneration. The results of the present study suggest that the administration of Coenzyme Q10 may be useful for the recuperation of liver function and a more favorable prognosis following the extended hepatectomy.