A prolonged case of drug-induced allergic hepatitis exhibiting the production of antibody to liver cell membrane

In the clinical course of drug-induced allergic hepatitis, the production of anti-liver cell membrane antibody was detected in patient's serum by an antibody-dependent cell-mediated cytotbxicity test. This allergic hepatitis was induced by administration of pamoic acid hydroxyzine and liver hedrolysate medicine (proheparum), and the sensitization to these drugs was proved by lymphocyte transformation test. Disorders of liver function were continued for a long time ever after stop of the drug administration and these were presumed to due to the production of antibody against liver specific antigen, because liver function disorders were in parallel with the production of antibody.