Prognostic parameters indicating progression from chronic hepatitis to liver cirrhosis

Clinical, biochemical, peritoneoscopic, histological and therapeutic features important for progression of chronic hepatitis (CH) to liver cirrhosis (LC) were evaluated in 177 CH patients by the life table method. The cumulative progression curve of Cox's multiregression life table method resembled that of Kaplan-Meier's method and 50% progression time was 10.2 years. Parameters important for the progression were histological classification (risk ratio, 5.4), HBsAg (3.0), code number of peritoneoscopy (2.5) and indocyanine green plasma disappearance rate (1.9) in the order of importance. Patients with chronic aggressive hepatitis; activity severe (CAH2B) progressed with a risk ratio of 5.4 times of those with chronic persistent hepatitis (CPH). Corticosteroid therapy did not stop the progression. Estimated 50% progression time of cases with CAH2B, 300's code number, positive HBsAg, chronic aggressive hepatitis; activity moderate (CAH2A), 200's, negative HBsAg and CPH, were 5.0, 5.2, 5.4, 7.8, 11.2, 14.1 and more than 20 years by Cox's method.