Establishment of high risk group for hepatocellular carcinoma using theory of quantification

Establishment of high risk group for hepatocellular carcinoma (HCC) was developed by analyses of common clinical data obtained when diagnosis of liver cirrhosis (LC) was confirmed. Sixty-one histologically proven cirrhotic patients were retrospectively divided into two groups: Group 1, 20 cases complicating HCC during more than one year follow up after the diagnosis of LC, Group 2, 41 cases alived more than 3 years without complicating HCC. Discriminant function for differentiating above-mentioned two groups was derived using the theory of quantification. Employing this function, correct differentiation was made in 36 out of 41 cases (87.8%) of LC and 19 out of 20 cases (95.0%) of HCC. Among parameters, the sex, LDH, GOT/GPT and history of both alcohol consumption and blood transfusion contributed greatly to the differentiation.