Two cases of ticlopidin hydrochloride induced hepatic injury

Two cases of ticlopidin hydrochloride induced hepatic injury

Two cases of ticlopidine induced hepatic injury were presented. Case I: A 70-year-old man was admitted to a hospital because of jaundice after administration of ticlopidine, 300mg/day for one week. Laboratory data was follows, GOT 32mu/ml, GPT 63mu/ml, T. Chol. 116mg/dl, T. Protein 6.4g/dl and so on...

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Veröffentlicht in:Kanzo 1985/09/25, Vol.26(9), pp.1224-1228
Hauptverfasser: MOTEGI, Kazumichi, YAMADA, Shoji, SAKURAI, Seiji, TAKEHARA, Takeshi, NAGAMINE, Takeaki, TAKEZAWA, Jiro, ICHIKAWA, Kunio, SAEKI, Shunichi, UEHARA, Masahiro, KOBAYASHI, Setsuo, SHIMOJO, Hiroshi, KONDO, Tadanori
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Ticlopidine hydrochloride
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container_end_page 1228
container_issue 9
container_start_page 1224
container_title Kanzo
container_volume 26
creator MOTEGI, Kazumichi
YAMADA, Shoji
SAKURAI, Seiji
TAKEHARA, Takeshi
NAGAMINE, Takeaki
TAKEZAWA, Jiro
ICHIKAWA, Kunio
SAEKI, Shunichi
UEHARA, Masahiro
KOBAYASHI, Setsuo
SHIMOJO, Hiroshi
KONDO, Tadanori
description Two cases of ticlopidine induced hepatic injury were presented. Case I: A 70-year-old man was admitted to a hospital because of jaundice after administration of ticlopidine, 300mg/day for one week. Laboratory data was follows, GOT 32mu/ml, GPT 63mu/ml, T. Chol. 116mg/dl, T. Protein 6.4g/dl and so on. Ticlopidine induced hepatic injury was diagnosed by LST. Liver biopsy specimens showed the hepatocellular damage with cholestasis. Case 2: a 80-year-old woman was admitted to a hospital because of cerebral infarction. She was poineted out hypertransaminasemia after administration of ticlopidine, 300mg/day for one month. 548% on LST for ticlopidine was positive. Recently, the incidence of application for anti-platelet agents has been increasing associated with increasing of adult diseases. It is necessary for us to consider the presence of hepatic injury when we administrate the anti-platelet agents.
doi_str_mv 10.2957/kanzo.26.1224
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language eng ; jpn
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source J-STAGE Free
subjects Ticlopidine hydrochloride
title Two cases of ticlopidin hydrochloride induced hepatic injury
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