Two cases of ticlopidin hydrochloride induced hepatic injury

Two cases of ticlopidine induced hepatic injury were presented. Case I: A 70-year-old man was admitted to a hospital because of jaundice after administration of ticlopidine, 300mg/day for one week. Laboratory data was follows, GOT 32mu/ml, GPT 63mu/ml, T. Chol. 116mg/dl, T. Protein 6.4g/dl and so on. Ticlopidine induced hepatic injury was diagnosed by LST. Liver biopsy specimens showed the hepatocellular damage with cholestasis. Case 2: a 80-year-old woman was admitted to a hospital because of cerebral infarction. She was poineted out hypertransaminasemia after administration of ticlopidine, 300mg/day for one month. 548% on LST for ticlopidine was positive. Recently, the incidence of application for anti-platelet agents has been increasing associated with increasing of adult diseases. It is necessary for us to consider the presence of hepatic injury when we administrate the anti-platelet agents.