Serum protein alteration in acute hepatic failure

For the purpose of early diagnosis of acute severe hepatitis from the view point of serum protein levels, a concentration of serum proteins, especially twenty kinds of serum subfraction, were measured simultaneously in fulminant hepatitis and subacute hepatitis by immunodiffusion. Other examined serum proteins are albumin, α1, α2, β, γ-globulin, prothrombin time and hepaplastin time. The levels of many kinds of serum proteins in acute severe hepatitis were compaired statistically with them in normal group, acute hepatitis and chronic liver diseases. Consequently, concentrations of almost all serum subfractior. except immunoglobulin in acute severe hepatitis were dropped in the most lower levels than that in any other liver diseases. Particulary, hemopexin, α2Hs-glycoprotein, haptoglobin, β1A/β1C globulin, prealbumin, transferrin and α1 acid glycoprotein were seemed to be reliable indices in early diagnosis and prognostic judgement of acute severe hepatitis. Hepaplastin time was important examination in this purpose, too. In acute severe hepatitis such as fulminant hepatitis and subacute hepatitis, a diagnostic pattern of serum subfraction was shown in this evaluation.