The study with the effects of antioxidant agent(α-tocopherol acete) influence on malonyl-dialdehyde & hexose monophosphate shunt in CCl4 administrated oryctologus cuniculus

This study was to investigate the relationship between oxidation-reduction system and hemolysis, especially in point of malonyl-dialdehyde (MDA) of RBC in CCl4 administrated liver disorders. Our results in acute phase for 4 weeks after injection of CCl4 obtained the increased resistance of RBC with Parpart's method due to protective factor in internal homeostasis, the lability of RBC membrane with H2O2 hemolysis test, increased concentration of MDA and low activity of catalase. Good effects which had decreased concentration of MDA, stability of RBC membrane and high activity of catalase after treating with α-tocopherol acetate (VE) were shown in our data. In acute phase of CCl4 liver disorders, our data concluded that hemolysis tendency was caused by oxidative effect, no concerning with hexose monophosphate shunt and had better effect on hemolysis by treating with VE but chronic phase no constant data to hemolysis were obtained.