The Mutual Influence of the State of the Lipid Spectrum of Blood and Content of Adipokines on the Clinical Course of Non-Alcoholic Fatty Liver Disease in the Presence of Comorbid Chronic Kidney Disease
The purpose of the study was to find out the probable mutual influence of the state of the lipid spectrum of blood and content of adipokines in blood: leptin, adiponectin on the clinical course of non-alcoholic fatty liver disease against the background of obesity depending on its form and the prese...
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Veröffentlicht in: | Ukraïnsʹkij žurnal medicini, bìologìï ta sportu bìologìï ta sportu, 2021-06, Vol.6 (3), p.148-155 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The purpose of the study was to find out the probable mutual influence of the state of the lipid spectrum of blood and content of adipokines in blood: leptin, adiponectin on the clinical course of non-alcoholic fatty liver disease against the background of obesity depending on its form and the presence of comorbid chronic kidney disease. Materials and methods. 444 patients were examined: of which 84 patients with non-alcoholic fatty liver disease with grade I obesity (group 1), which contained 2 subgroups: 32 patients with non-alcoholic hepatic steatosis and 52 patients with non-alcoholic steatohepatitis; 270 patients with non-alcoholic fatty liver disease with comorbid obesity of the I degree and chronic kidney disease of the I-III stage (group 2), including 110 patients with non-alcoholic steatosis of the liver and 160 patients with non-alcoholic steatohepatitis. The control group consisted of 90 patients with chronic kidney disease stage I-III with normal body weight (group 3). The mean age of patients was (45.8±3.81) years. Results and discussion. The study showed that patients with non-alcoholic steatohepatitis and obesity without concomitant chronic kidney disease are characterized by the following changes in the blood lipid spectrum: maximum increase in blood triacylglycerols (by 2.1 times, p |
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ISSN: | 2415-3060 2522-4972 |
DOI: | 10.26693/jmbs06.03.148 |