Aluminium and its Derivatives Causing Genotoxicity and its Underlying Mechanism

Aluminium is a metal that is obtained from the piles of earth crust naturally and it is used in most of our daily needs. The aluminium is mostly found in combined form with other elements. The development of nanotechnology has created wide impact on the present situation and it is been utilized the most. Most of the metals such as aluminium has been developed in to nanoparticles for potential advantages but aluminium is known to be a toxic metal whose genotoxicity more generally in mammals.Where the Mutations caused by it induces permanent changes in the DNA sequence of an organism which may result in a heritable change in the characteristics of living systems. The possible mechanisms by which Al induces DNA damage and inhibits the repair are discussed below this damage is found by the chromosomal aberration and micronucleus assay methods. Aluminium derivatives are also known to possess this property of genotoxicity and mutagenicity which is been reported earlier. In this study we explore the different mechanism through which genotoxicity is been assessed and some of the aluminium derivatives that are known to act through those mechanisms and also to know its effect as a nanoparticle in few.nbsp