Formulation and Evaluation of Paroxetine Hydrochloride Loaded Thermoreversible In situ Intranasal Gel

Aim The present work aimed to develop and evaluate Paroxetine HCl thermoreversible and mucoadhesive in situ intranasal gel.Methodology Carbopol 934P and poloxamer 407 have been utilized for the development of Paroxetine HCl thermoreversible and mucoadhesive in situ intranasal gel. The cold technique was used to formulate in situ intranasal gel. Evaluation of physico-chemical parameters clarity viscosity pH drug content and mucoadhesive strength was performed for intranasal in situ gel. In vitro drug release studies ex-vivo permeation studies and stability studies were conducted for all the formulations.Results A 19 wv of poloxamer 407 solution showed phase transition temperature at physiologic conditions 32ndash34o C. The mucoadhesive strength was found to be below 7000 dynescm2 till 0.4 wv concentration of carbopol 934P. Gelation temperature of formulation A4 was found to be satisfactory. Mucoadhesive strength in all the formulations was shown to be above 4000 dynescm2 . The gelation time and gel melting temperature of all the formulations showed uniformity. In vitro drug release was in the range of 54.8 to 83.22 in 8 h. Ex vivo drug release of the optimized A4 formulation was found to be 82.3 in 8h. All the formulations were found stable except A5.Conclusion Based on the results of in vitro and ex vivo studies the A4 formulation was found to be optimum. Thus the present work concluded that Paroxetine HCl thermoreversible in situ intranasal gel is safe and effective for treating depression.