Evaluation of Platelet-Neutrophil and Platelet - Monocyte Ratio in Healthy Subjects and Chronic Periodontitis Patients - A Clinical and Biochemical Analysis

Background The aim of this study was to evaluate platelet-neutrophil and platelet-monocyte ratios in healthy subjects and chronic periodontitis patients before and after two weeks of non-surgical periodontal therapy to assess whether the amount of periodontal inflammation in these subjects can influence the peripheral blood cell levels.Methods Subjects for this study were divided into two groups Group A including 10 periodontally healthy controls and Group B including 10 chronic periodontitis patients. Collection of blood samples was carried out before and after two weeks of non-surgical periodontal therapy.Results In the present study the platelet neutrophil ratio in group B 23.12plusmn2.40 was greater than group A 19.57plusmn2.49 at baseline and the difference was statistically significant Mean diff -3.55 P value 0.009. The platelet- monocyte ratio in group A 1.10plusmn0.83 was higher than group B 0.66plusmn0.60 at baseline. Conclusion From the results of the present study we tend to conclude that chronic periodontal disease may alter the leucocyte and platelet counts compared to healthy patients and might be considered as one of the mechanisms elucidating the connection between periodontitis and the onset of atherosclerosis and cardiovascular disease.