Photodynamic Therapy (PDT) and Diagnosis (PDD) with a Dendrimer Photosensitizer-encapsulated Polymeric Micelle

Photodynamic Therapy (PDT) and Diagnosis (PDD) with a Dendrimer Photosensitizer-encapsulated Polymeric Micelle

Photodynamic therapy (PDT) and photodynamic diagnosis (PDD) have attracted much attention as relatively noninvasive methods for cancer treatment and diagnosis, and new photosensitizers with a property of high accumulation in tumors have been extensively investigated. The use of a drug-delivery syste...

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Veröffentlicht in:Nihon Rēzā Igakkai shi 2012/08/31, Vol.33(2), pp.104-109
Hauptverfasser: Hiruma, Hitomi, Morimoto, Yuji, Miyazaki, Kozo, Inoue, Aki, Nomoto, Takahiro, Fukushima, Shigeto, Shinomiya, Nariyoshi, Nishiyama, Nobuhiro, Kataoka, Kazunori
Format: Artikel
Sprache:eng
Schlagworte:
drug delivery system
photodynamic diagnosis
photodynamic therapy
photosensitizer
polymeric micelle
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Zusammenfassung:Photodynamic therapy (PDT) and photodynamic diagnosis (PDD) have attracted much attention as relatively noninvasive methods for cancer treatment and diagnosis, and new photosensitizers with a property of high accumulation in tumors have been extensively investigated. The use of a drug-delivery system (DDS) for the delivery of photosensitizers is a promising approach for improved safety and enhanced efficacy of PDT and PDD. We established a novel DDS-type photosensitizer, a dendrimer photosensitizer-encapsulated polymeric micelle. In this review, the design of the agent and its usefulness in PDT and PDT are shown.
ISSN:0288-6200
1881-1639
DOI:10.2530/jslsm.33.104