Hepatoprotective and Antioxidant Activity of Stem and Leaves Parts of Cissus woodrowii (Stapf ex Cooke) Santapau

The contemporary investigation aimed to assess the hepatoprotective potential of Cissus woodrowii (Stapf ex Cooke) Santapau against carbon tetrachloride-induced hepatotoxicity. Through evaluating antioxidant levels in liver tissues and blood marker enzymes, it was observed that administration of the plant extract at doses of 200 and 400 mg/kg significantly mitigated liver damage caused by carbon tetrachloride. The study found that carbon tetrachloride-induced reductions in total protein, catalase, glutathione (GSH), and superoxide dismutase (SOD) levels, while increasing levels of alkaline phosphatase, alanine aminotransferase, total bilirubin, lipid peroxidation, and aspartate aminotransferase. However, rats treated with varying doses of the plant extract exhibited restoration towards normal levels of serum marker enzymes and antioxidants, contrasting with those solely exposed to carbon tetrachloride. These findings collectively suggest that C. woodrowii (Stapf ex Cooke) Santapau possesses antioxidant properties and exerts a hepato-protective effect against CCl4-induced liver impairment in rats.