Diuretic Activity of Hydroalcoholic Extract of Peristrophe bicalyculata (R.) Nees. Leaves in Saline Loaded Rats

Peristrophe bicalyculata (R.) Nees. (PB) is one of the most widely medicinal plants used in ancient folklore to treat a number of diseases. In the present investigation, the diuretic activity of hydroalcoholic extract of leaves of selected plant was evaluated in saline-loaded rats. Rats weighing in between 180 to 200 gm of either sex were taken for the present study and concentration of urinary NA+K+ and Cl- was determined to access the memorandum of association (MOA). The hydroalcoholic extract of PB leaves at the test dose of 250 mg/kg bw showed significant diuresis in 3 hours while at the test dose of 500 mg/kg bw produced substantial diuresis at the end of 4 hours.