Case Report of Reactive Angioendotheliomatosis

Reactive angioendotheliomatosis (RAE) is a rare, typically self-limiting, angioproliferative disease that is commonly seen in patients with a variety of inflammatory and systemic diseases. RAE can clinically present as ulcerated, single or multifocal, violaceous papules or plaques. We report a case of a 59-year-old male with a complicated cardiac history who presented with biopsy-proven RAE on the thigh. The differential diagnosis of RAE can include Kaposi sarcoma and angiosarcoma, as well as other non-malignant cutaneous disease. These diagnoses must be excluded before correctly diagnosing and treating RAE. We review the common presentation of RAE along with criteria to exclude other possible diagnoses that can resemble RAE.