Contribution of Therapeutic Monitoring in the Assessment of Toxic Adverse Effects of Mitotane: a Case Report

Contribution of Therapeutic Monitoring in the Assessment of Toxic Adverse Effects of Mitotane: a Case Report

Mitotane provided serious side effects and low doses seemed to be tolerated. Determination of mitotane concentration in plasma is recommended. We report the case of toxic plasma levels with low doses of mitotane in a 47-year-old man with adrenocortical cancer. Le mitotane a des effets secondaires gr...

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Veröffentlicht in:Therapie 2015-11, Vol.70 (6), p.545-546
Hauptverfasser: Jebabli, Nadia, Gaïes, Emna, Eljebari, Hanen, Charfi, Rim, Lakhal, Mohamed, Klouz, Anis, Salouage, Issam, Trabelsi, Sameh
Format: Artikel
Sprache:fre
Schlagworte:
concentrations plasmatiques
intoxication au mitotane
mitotane
mitotane intoxication
plasmatic level
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Zusammenfassung:Mitotane provided serious side effects and low doses seemed to be tolerated. Determination of mitotane concentration in plasma is recommended. We report the case of toxic plasma levels with low doses of mitotane in a 47-year-old man with adrenocortical cancer. Le mitotane a des effets secondaires graves ; son utilisation à des doses faibles semble être tolérée. Le dosage de la concentration plasmatique du mitotane est recommandé. Nous rapportons le cas d’un homme âgé de 47 ans ayant un cancer corticosurrénalien ayant des concentrations plasmatiques toxique avec des doses faible de mitotane.
ISSN:0040-5957
DOI:10.2515/therapie/2015043