Immunohistochemical Evaluation of Expression of p53 and PCNA in Oral Squamous Cell Carcinoma

Immunohistochemical Evaluation of Expression of p53 and PCNA in Oral Squamous Cell Carcinoma

The proliferative activity of cancer cells in oral squamous cell carcinoma has been identified as an important predicator of biologic behavior and as a potential guide for cancer therapy. The proliferative capacity was analyzed immunohistochemically using monoclonal antibody against PCNA and p53 pro...

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Veröffentlicht in:The Journal of the Kyushu Dental Society 1997/06/25, Vol.51(3), pp.375-382
Hauptverfasser: Kurokawa, Hideo, Murata, Tomoyuki, Yamashita, Yoshihiro, Tokudome, Shingo, Miura, Keiko, Yoshikawa, Tsutomu, Kajiyama, Minoru
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
53 protein
Immunohistochemistry
Oral squamous cell carcinoma
Proliferating cell nuclear antigen (PCNA)
Proliferative activity
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Zusammenfassung:The proliferative activity of cancer cells in oral squamous cell carcinoma has been identified as an important predicator of biologic behavior and as a potential guide for cancer therapy. The proliferative capacity was analyzed immunohistochemically using monoclonal antibody against PCNA and p53 protein in biopsy or surgical resected specimens from 51 cases with oral squamous cell carcinoma (SCC). The results were as follows : 1) There was a significant difference in PCNA score between p53 protein-positive cases and p53 protein-negative cases ; 37.9±11.9% (n=28), 30.8±11.1% (n=23)(p
ISSN:0368-6833
1880-8719
DOI:10.2504/kds.51.375