SYNTHESIS AND IN-VITRO ANTI-MICROBIAL EVALUATION OF NOVEL HYDRAZONES OF SUBSTITUTED TETRAHYDROPYRIMIDINES

This research article describes the synthesis of phenyl hydrazone derivatives of 5-acetyl-6-methyl-4-substituted phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidines, as no derivatization has been reported at carbonyl functionality at position 5 of corresponding rings till date. The prepared derivatives were characterised using modern spectral techniques and were screened for their in-vitro anti-microbial activities by agar diffusion method. Among synthesised derivatives [II(a-g)], compound II(f) was found to be the most potent anti-bacterial agent and rest of the compounds had shown moderate to weak anti-bacterial activity.