Study on Deep Vein Thrombosis with Thrombophilia

We retrospectively studied the correlative recurrences of deep vein thrombosis (DVT) and thrombophilia in 258 patients with DVT. Subjects were followed for 4 to 115 months (mean 34 months). Recurrences were seen in 12 of 258 patients. The presence of thrombophilia in DVT was observed in 8 of 98 patients (3 with antithrombin III deficiency, 3 with protein C deficiency, 1 with protein S deficiency, 1 with antiphospholipid syndrome), and recurrent DVT with thrombophilia was seen in 5 of 12 patients with recurrent DVT. Recurrence of DVT occured from 1 to 36 months after halting warfarin therapy. In conclusion, long term warfarin therapy is necessary for the prevention of recurrent DVT with thrombophilia.