Medicinal Species of The Genus Croton (Euphorbiaceae): a Worldwide View on the Dynamics and Evolution of Scientific Production

Objective: the present study aimed to gather scientific information on a worldwide level about publications on the Croton genus, with the identification of the main medicinal species, their bioactive compounds and medicinal uses, using information published in journals and different and complementary references in the area of applied botany, supporting research with species of this genus. Theoretical framework: Croton genus is one of the largest of the Euphorbiaceae family and contains approximately 1,300 species, many of which used in traditional medicine for treating stomach disease, abscess, inflammation, and malaria. The use of bibliometric surveys has been developing for years, grouping information and aiding decision-making in all areas, especially human health and environmental sciences. Method: Web of Science platform was used to obtain data, we compiled the documents found considering various information. For the analysis, the Bibliometrix package from the RStudio software was used, as well as the IRAMUTEQ software. Results and conclusion: mapping of scientific production recorded 64 species in the 354 papers found, in investigation or confirmation of medicinal potential. The main bioactivities examined were the anti-inflammatory, antimicrobial, antioxidant, antinociceptive, anticancer, and antimalaria actions. Research implications: Brazil stood out in the following aspects: number of publications, collaborations, and affiliations with active research about the genus, which can be attributed to the genus’ degree of endemism in this country. Originality/value: this unprecedented study constitutes relevant support for future research involving the bioactive potential of new Croton species and even other plants of popular medicinal use.